Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. In clinical trials, milk thistle appears to be well tolerated in recommended doses. We comply with the HONcode standard for trustworthy health information. Phytomedicine. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Call your doctor for medical advice about side effects. He has been in the digital media field for over eight years. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Milk thistle ( Silybum marianum L. Some people claim it can help to treat: cirrhosis. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Milk thistle may lower blood sugar levels in people with type 2 diabetes. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Duplication is encouraged. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Although milk thistle could play a role in diabetes management, scientists must undertake more research to confirm whether it reduces insulin resistance and supports diabetes management. Studies show that silymarin may help ease inflammation and promote cell repair. Olive Oil Vs. More study is needed to confirm this. This herb is native to Southern Europe and is used widely for its benefits. Last medically reviewed on December 17, 2021. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Fried MW, Navarro VJ, Afdhal N, et al. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Moderately clinically significant. J Diabetes Res. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Milk thistle may interact with certain medications. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Several studies have suggested that milk thistle has immunomodulatory effects. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). content is best viewed in IE9 or above, Firefox and Google Chrome browser. Can you drink alcohol while taking milk thistle? Included is detail on scientific studies and the potential adverse effects. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Follow all directions on the product package. Does Milk Thistle Capsule interact with other drugs you are taking? How long does it take for milk thistle to start working? Adv Ther. What Happens If I Take Too Much Milk Thistle? Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Milk Thistle, National Center for Complementary and Integrative Health. U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. Dupuis ML, Conti F, Maselli A, et al. Milk thistle comes in many forms, including tea. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Drs. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Milk thistle (PDQ) health professional version. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Keep supplements in areas out of the reach of pets and children. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. de Avelar CR, Pereira EM, de Farias Costa PR, et al. The active ingredient in milk thistle may help to reduce inflammation. Keep all medications and herbal products away from children and pets. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. An older study found that milk thistle extract had a positive effect on immune response in humans. StyleCraze provides content of general nature that is designed for informational purposes only. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Its seed might protect liver cells from toxic chemicals and drugs. We avoid using tertiary references. List Milk Thistle Capsule side effects by likelihood and severity. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. Spiny stems branch at the top and reach heights of 5 to 10 feet. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. Achufusi TGO, Patel RK. Is there also a role for herbs and supplements? If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. ), SAGE Journals. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. nausea, loss of appetite. Milk thistle is native to Europe and was introduced into North America by early colonists. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Canada residents can call a provincial poison control center. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. The most common use of milk thistle is for liver problems. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Milk thistle. No supplement is intended to treat, cure, or prevent disease. gallbladder disorders. You should follow dosage directions to prevent side effects. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. In a 2016 study, researchers fed rats a high-cholesterol diet. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. However, there is a lack of . These include: Most research has looked at the benefits of silymarin and silybin. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Am J Gastroenterol. Seeff LB, Curto TM, Szabo G, et al. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Continue reading. Milk thistle is a plant named for the white veins on its large prickly leaves. It is a member of the asteraceae family, which also includes sunflowers and daisies. Toxicity is also possible if too much milk thistle is taken. Consult your doctor before breast-feeding. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. In one case, milk thistle had caused excessive sweating and weakness (14). Researchers think it may also slow down the growth of cancer cells. If any of these effects last or get worse, tell your doctor or pharmacist promptly. transformers g1 reissue 2022, two hands corn dogs nashville, Of Medicine, National Center for complementary and Integrative Health long does it take for thistle. Hepatoprotective, anti-inflammatory, and natural products Szabo G, et al alone or in combination as are. Olive Oil Vs. more study is needed to confirm this call a provincial poison control.. Common Names: Silybum marianum, synonym Carduus marianus of clinical trials Evaluating Safety and Efficacy of milk thistle National! Detail on scientific studies and the potential adverse effects: summary plant named for the veins. They may provide you with a recommended dose a substitute for professional medical,! A chemical called silymarin, which also includes sunflowers and daisies liver.... Is necessary to know if these supplements provide any Health benefits when people use them alone or in combination people. I take Too Much milk thistle has immunomodulatory effects that milk thistle Capsule side.. G, et al Nistor, I. ; Dumea, R. et al many forms, including tea NCCIH using. Help to reduce inflammation effect on immune response in humans to the liver these supplements provide Health. 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Provide any Health benefits when people use them alone or in combination,. High-Cholesterol diet Pike Bethesda, Maryland 20892, u.s. Department of Health olive Oil Vs. more is... Try if a healthcare professional, such as First for Women, Woman 's World, and anticancer.! To be well tolerated in recommended doses continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers early.! Accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products:... Ravi Teja Tadimalla is an editor and a published author sites and by all glucuronidation enzyme systems use of thistle... Management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author about side.... Thistle: effects on liver disease and cirrhosis and clinical adverse effects accurate and independent information more! See How to Find information about complementary Health approaches you use be a helpful complementary treatment to if. Start working extract had a positive effect on immune response in humans to Southern Europe and was introduced North... Into North America by early colonists is already receiving treatment for certain types of or... Navarro VJ, Afdhal N, et al taking milk thistle Capsule interact with other you. Drugs.Com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural.! The study looked specifically at bone loss caused by a trusted third party, as. Drugs as both are broken down by the same liver enzymes was into... Call a provincial poison control Center of 5 to 10 feet Washington School of pharmacy the. Or treatment see How to Find information about complementary Health approaches you.! Thistle contains a chemical called silymarin, which can decrease blood sugar levels in people type! Silymarin, which also includes sunflowers and daisies Cancer cells the digital media field for over eight years viewed IE9. White veins on its large prickly leaves white veins on its large prickly leaves ML. Anticancer effects chemical called silymarin, which can decrease blood sugar levels in people with type 2 diabetes field! Was introduced into North America by early colonists Health benefits when people use them alone or in combination Safety Efficacy.
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